HHATL-AS1

Across TCGA pan-cancer cohorts, HHATL-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HHATL-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HHATL-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HHATL-AS1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where HHATL-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HHATL-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.167	<.001	11	view →
COAD	All	IV	−0.162	<.001	11	view →
THCA	Male	All	−0.647	<.001	10	view →
LUAD	Female	All	−0.609	<.001	8	view →
HNSC	Male	All	−0.150	<.001	8	view →
LUSC	Male	II,III,IV	−0.770	<.001	6	view →
KIRP	Female	II,III,IV	−0.348	.046	2	view →
LIHC	All	All	+0.146	.011	2	view →
READ	All	All	−0.126	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HHATL-AS1–KIRC

Open the KIRC breakdown →