HHAT

Across TCGA patient cohorts, HHAT mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHAT-associated genes across cancer lineages are Rad50, IGFBP2, and p21. Each is linked with HHAT in more than 1 cancer types. Because this analysis shows association rather than direction, both HHAT-to-partner and partner-to-HHAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by HHAT-low versus HHAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHAT→partner) and Y-score (partner→HHAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.282	-2.807	.007	.003	3	2
UCEC	IGFBP2 →	-0.879	-2.115	.001	.019	3	1
UCEC	p21 →	+0.169	+3.000	.044	.036	3	1
UCEC	p62 Lck ligand →	+0.527	+3.906	<.001	<.001	3	1
UCEC	P-Cadherin →	-0.125	-2.999	.048	.035	3	1
UCEC	PCNA →	+0.231	+2.999	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Rad50 by HHAT expression — UCEC

Explore this box plot interactively →