HGSNAT

Across TCGA patient cohorts, HGSNAT mutation is significantly associated with the RNA expression of many other genes, with 2,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HGSNAT-associated genes across cancer lineages are SFPQP1, AURKB, and COX6CP12. Each is linked with HGSNAT in more than 2 cancer types. Because this analysis shows association rather than direction, both HGSNAT-to-partner and partner-to-HGSNAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFPQP1 grouped by HGSNAT-low versus HGSNAT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HGSNAT→partner) and Y-score (partner→HGSNAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SFPQP1 →	+0.071	+3.076	<.001	.005	3	3
UCEC	AURKB →	+0.642	+3.711	.001	<.001	3	3
LUSC	COX6CP12 →	+0.134	+5.321	<.001	.002	3	3
LUSC	CDRT8 →	+0.251	+5.006	<.001	<.001	3	3
COAD	TXN2P1 →	+0.522	+3.666	.007	.002	3	2
CESC	LINC01941 →	+0.138	+5.669	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,350 associations by consensus.

SFPQP1 by HGSNAT expression — SKCM

Explore this box plot interactively →