HGH1

Across TCGA pan-cancer cohorts, HGH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HGH1 data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HGH1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HGH1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and OV are the cancer types where HGH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.947	0.690	<.001	17	view →
HNSC	OS	Median	IV	0.842	0.605	.010	12	view →
OV	DFS	Median	All	0.854	1.000	.032	4	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
LUAD	OS	Median	III,IV	0.756	0.336	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HGH1–LSCC (DFS)

Open the LSCC breakdown →