HEYL

Across TCGA patient cohorts, HEYL mutation is significantly associated with the RNA expression of many other genes, with 1,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEYL-associated genes across cancer lineages are OR5K1, TRAJ57, and RNU6-937P. Each is linked with HEYL in more than 1 cancer types. Because this analysis shows association rather than direction, both HEYL-to-partner and partner-to-HEYL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5K1 grouped by HEYL-low versus HEYL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEYL→partner) and Y-score (partner→HEYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5K1 →	+0.023	+4.797	<.001	.003	3	2
BRCA	TRAJ57 →	+0.527	+5.230	.003	.007	3	2
UCEC	RNU6-937P →	+0.357	+2.078	.005	.002	3	2
UCEC	KIR3DL1 →	+0.186	+2.087	.002	.006	3	2
UCEC	RNU6-1153P →	+0.487	+2.204	.006	.001	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,819 associations by consensus.

OR5K1 by HEYL expression — SKCM

Explore this box plot interactively →