HEY1

Across TCGA patient cohorts, HEY1 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEY1-associated genes across cancer lineages are GAGE2E, MTCO2P34, and IGLJ7. Each is linked with HEY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEY1-to-partner and partner-to-HEY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE2E grouped by HEY1-low versus HEY1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEY1→partner) and Y-score (partner→HEY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAGE2E →	+0.233	+6.234	<.001	<.001	3	2
READ	MTCO2P34 →	+0.219	+4.925	<.001	.004	3	2
UCEC	IGLJ7 →	+1.566	+3.153	.002	.006	3	2
UCEC	MTND4P18 →	+0.138	+4.398	.001	<.001	3	2
UCEC	VTRNA2-2P →	+0.532	+3.204	.003	.006	3	2
BRCA	WBP1LP8 →	+0.037	+7.473	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

GAGE2E by HEY1 expression — BRCA

Explore this box plot interactively →