HEY1

Across TCGA pan-cancer cohorts, HEY1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HEY1 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HEY1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HEY1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRP, KIRC, and LIHC are the cancer types where HEY1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.580	0.769	<.001	99	view →
KIRC	DFS	Median	III,IV	0.613	0.327	<.001	98	view →
LIHC	DFS	Tertile	All	0.444	0.619	<.001	74	view →
UVM	DFS	Tertile	III,IV	0.333	0.761	.002	58	view →
MESO	OS	Tertile	All	0.251	0.490	.002	47	view →
LGG	DFS	Median	All	0.805	0.663	<.001	39	view →
ACC	OS	Tertile	II,III,IV	0.644	1.000	.007	29	view →
BLCA	DFS	Quartile	IV	0.236	0.700	<.001	25	view →
STAD	OS	Quartile	II,III,IV	0.476	0.675	.025	24	view →
SCLC	OS	Quartile	II,III,IV	0.624	0.236	.014	16	view →
HNSC	OS	Tertile	All	0.281	0.476	.007	13	view →
PAAD	OS	Quartile	All	0.611	0.253	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HEY1–KIRP (OS)

Open the KIRP breakdown →