HEXIM2

Across TCGA cell cohorts, HEXIM2 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEXIM2-associated genes across cancer lineages are AZD6094, AZD1332, and Bleomycin. Each is linked with HEXIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXIM2-to-partner and partner-to-HEXIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD6094 grouped by HEXIM2-low versus HEXIM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXIM2→partner) and Y-score (partner→HEXIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD6094 →	+0.204	+2.649	.018	.046	3	1
LARGE_INTESTINE	AZD1332 →	+0.564	+2.649	.027	.046	3	1
LARGE_INTESTINE	Bleomycin →	+0.399	+2.649	.046	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.494	+2.672	.049	.039	3	1
LARGE_INTESTINE	SU11274 →	+0.441	+2.652	.034	.045	3	1
LARGE_INTESTINE	CD532 →	+0.567	+2.652	.004	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

AZD6094 by HEXIM2 expression — LARGE_INTESTINE

Explore this box plot interactively →