HEXIM2

Across TCGA pan-cancer cohorts, HEXIM2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated HEXIM2 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HEXIM2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HEXIM2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, MESO, and UVM are the cancer types where HEXIM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.478	0.276	.001	115	view →
MESO	OS	Median	All	0.519	0.262	<.001	97	view →
UVM	DFS	Tertile	All	0.493	0.915	.001	57	view →
UCEC	OS	Median	III,IV	0.753	0.441	.003	36	view →
BRCA	OS	Median	II,III,IV	0.942	0.884	.002	36	view →
ACC	DFS	Tertile	All	0.348	0.755	<.001	35	view →
LIHC	DFS	Quartile	All	0.327	0.496	.001	33	view →
PAAD	DFS	Median	All	0.438	0.268	.002	31	view →
OV	DFS	Median	All	0.583	0.499	.008	30	view →
KICH	DFS	Tertile	III,IV	0.362	1.000	.003	28	view →
READ	OS	Median	All	0.977	0.848	.002	26	view →
ESCA	DFS	Median	All	1.000	0.465	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

HEXIM2–HNSC (OS)

Open the HNSC breakdown →