HEXD

Across TCGA patient cohorts, HEXD RNA expression is significantly associated with the go_rna of many other GO terms, with 7,163 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible HEXD-associated GO terms across cancer lineages are Depyrimidination, Base-excision repair, AP site formation, and Spermidine metabolic process. Each is linked with HEXD in more than 26 cancer types. Because this analysis shows association rather than direction, both HEXD-to-partner and partner-to-HEXD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Depyrimidination grouped by HEXD-low versus HEXD-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXD→partner) and Y-score (partner→HEXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Depyrimidination →	+0.063	+0.638	<.001	<.001	3	27
KIRP	Base-excision repair, AP site formation →	+0.084	+1.074	<.001	<.001	3	25
CHOL	Spermidine metabolic process →	+0.064	+0.861	.001	.001	2	26
UCS	Regulation of telomere maintenance in response to DNA damage →	+0.051	+0.927	.001	<.001	2	26
KIRC	Obsolete regulation of histone modification →	+0.044	+0.569	<.001	<.001	3	24
SCLC	Positive regulation of DNA repair →	+0.080	+0.951	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,163 associations by consensus.

Depyrimidination by HEXD expression — KIRC

Explore this box plot interactively →