HEXD

Across TCGA pan-cancer cohorts, HEXD RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HEXD data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HEXD RNA is associated with better overall survival. In most high-consensus cancer types, elevated HEXD expression acts as an unfavorable survival marker, although some lineages such as BLCA and MESO show a favorable association.

BLCA, MESO, and ACC are the cancer types where HEXD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.773	0.645	<.001	85	view →
MESO	OS	Median	All	0.681	0.404	<.001	74	view →
ACC	DFS	Tertile	All	0.244	0.661	.001	49	view →
SKCM	DFS	Quartile	All	0.702	0.525	<.001	47	view →
HNSC	OS	Quartile	III,IV	0.776	0.554	.003	37	view →
PAAD	OS	Median	All	0.489	0.244	.004	25	view →
PRAD	DFS	Median	All	0.680	0.902	<.001	24	view →
COAD	DFS	Quartile	II,III,IV	0.329	0.753	.013	12	view →
THCA	DFS	Quartile	All	0.902	0.711	.002	12	view →
LIHC	DFS	Median	All	0.485	0.596	.010	11	view →
BRCA	OS	Quartile	III,IV	0.824	0.532	.004	8	view →
KIRC	DFS	Quartile	IV	0.526	0.760	.032	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HEXD–BLCA (OS)

Open the BLCA breakdown →