HEXD

Across TCGA patient cohorts, HEXD protein abundance is significantly associated with the RNA expression of many other genes, with 5,418 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HEXD-associated genes across cancer lineages are EIF3J-DT, B4GALNT4, and SNORA22B. Each is linked with HEXD in more than 3 cancer types. Because this analysis shows association rather than direction, both HEXD-to-partner and partner-to-HEXD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HEXD versus EIF3J-DT in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXD→partner) and Y-score (partner→HEXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EIF3J-DT →	+0.375	+0.297	<.001	<.001	3	4
CCRCC	B4GALNT4 →	-1.296	-0.654	<.001	<.001	3	3
HNSC	SNORA22B →	-1.037	-0.448	<.001	<.001	3	3
BRCA	CCNE1 →	-1.189	-0.380	<.001	<.001	3	3
UCEC	PLSCR4 →	+0.882	+0.311	.001	.002	3	3
BRCA	ETFBKMT →	+0.457	+0.334	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,418 associations by consensus.

HEXD vs EIF3J-DT — BRCA

Explore this scatter interactively →