HEXD

Across TCGA patient cohorts, HEXD mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEXD-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with HEXD in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXD-to-partner and partner-to-HEXD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HEXD-low versus HEXD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXD→partner) and Y-score (partner→HEXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.418	-1.765	.014	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+1.069	+3.906	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.110	-2.195	.003	.009	3	1
UCEC	EGFR →	-0.201	-1.415	<.001	.046	3	1
UCEC	MEK1 →	+0.360	+3.807	.008	<.001	3	1
UCEC	MSH2 →	-0.331	-1.973	<.001	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by HEXD expression — UCEC

Explore this box plot interactively →