HEXD

Across TCGA cell cohorts, HEXD RNA expression is significantly associated with the go_rna of many other GO terms, with 4,021 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HEXD-associated GO terms across cancer lineages are mRNA splice site recognition, Negative regulation of myoblast fusion, and Cilium or flagellum-dependent cell motility. Each is linked with HEXD in more than 16 cancer types. Because this analysis shows association rather than direction, both HEXD-to-partner and partner-to-HEXD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by HEXD-low versus HEXD-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXD→partner) and Y-score (partner→HEXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	mRNA splice site recognition →	+0.187	+1.611	<.001	<.001	3	17
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.176	+1.448	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.130	-1.866	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.130	-1.866	<.001	<.001	3	17
OESOPHAGUS	Cilium movement involved in cell motility →	-0.116	-1.584	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.144	-1.660	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,021 associations by consensus.

mRNA splice site recognition by HEXD expression — OESOPHAGUS

Explore this box plot interactively →