HEXD

Across TCGA cell cohorts, HEXD mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HEXD-associated genes across cancer lineages are GSG1L, MSH4, and SPRR2B. Each is linked with HEXD in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXD-to-partner and partner-to-HEXD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L grouped by HEXD-low versus HEXD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXD→partner) and Y-score (partner→HEXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L →	+0.298	+3.559	<.001	.005	3	2
BLOOD_Leukemia	MSH4 →	+0.167	+3.318	<.001	.007	3	2
LUNG_NSCLC_LUAD	SPRR2B →	+0.037	+4.887	<.001	.009	3	1
BLOOD_Leukemia	TNFSF8 →	+1.366	+3.672	.005	.003	3	1
BLOOD_Leukemia	ONECUT1 →	+0.483	+3.257	.008	.009	3	1
BLOOD_Leukemia	SNTG2 →	+1.026	+3.491	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GSG1L by HEXD expression — BLOOD_Leukemia

Explore this box plot interactively →