HEXD

Across TCGA cell cohorts, HEXD mutation is significantly associated with the mutation status of many other genes, with 5,178 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEXD-associated genes across cancer lineages are TMC2, WWC1, and WDR3. Each is linked with HEXD in more than 4 cancer types. Because this analysis shows association rather than direction, both HEXD-to-partner and partner-to-HEXD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMC2 grouped by HEXD-low versus HEXD-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXD→partner) and Y-score (partner→HEXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TMC2 →	+4.429	+5.247	.005	.005	1	5
BLOOD_Leukemia	WWC1 →	+3.343	+3.125	<.001	<.001	1	5
BREAST	WDR3 →	+4.297	+4.857	.009	.009	1	4
BREAST	XAB2 →	+4.297	+4.857	.009	.009	1	4
BREAST	SYNJ2 →	+4.297	+4.857	.009	.009	1	4
LUNG_NSCLC_LUAD	RPGRIP1L →	+4.187	+5.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,178 associations by consensus.

TMC2 by HEXD expression — BLOOD_Lymphoma

Explore this box plot interactively →