HEXD-IT1

Across TCGA pan-cancer cohorts, HEXD-IT1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HEXD-IT1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HEXD-IT1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HEXD-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and PAAD are the cancer types where HEXD-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.471	0.261	<.001	139	view →
BRCA	OS	Tertile	III,IV	0.948	0.806	.001	47	view →
PAAD	OS	Quartile	All	0.628	0.279	<.001	44	view →
BLCA	DFS	Tertile	All	0.706	0.524	.001	40	view →
UVM	DFS	Median	All	0.263	0.722	<.001	31	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
SKCM	DFS	Tertile	III,IV	0.665	0.503	.012	21	view →
PRAD	DFS	Tertile	All	0.692	0.812	.003	20	view →
LUAD	DFS	Median	IV	0.306	0.764	.010	18	view →
COAD	OS	Quartile	All	0.372	0.628	.003	17	view →
STAD	OS	Quartile	II,III,IV	0.813	0.441	.014	16	view →
KIRC	DFS	Quartile	All	0.598	0.730	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HEXD-IT1–HNSC (OS)

Open the HNSC breakdown →