HEXD-IT1

Across TCGA pan-cancer cohorts, HEXD-IT1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HEXD-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where HEXD-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HEXD-IT1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

LIHC, CHOL, and THCA are the cancer types where HEXD-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEXD-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.111	<.001	7	view →
CHOL	All	All	+0.555	<.001	5	view →
THCA	Female	II,III,IV	−0.317	.012	4	view →
UCEC	All	All	−0.283	.004	4	view →
COAD	Male	All	+0.164	.014	4	view →
BRCA	All	III,IV	−0.176	.034	2	view →
KICH	All	II,III,IV	+0.150	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HEXD-IT1–LIHC

Open the LIHC breakdown →