HEXB

Across TCGA pan-cancer cohorts, HEXB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HEXB data layer compared with 30 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HEXB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HEXB expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where HEXB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.881	1.000	.012	72	view →
LUAD	OS	Median	All	1.000	0.625	.001	27	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	23	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	10	view →
OV	DFS	Median	All	0.658	0.923	.032	8	view →
PDAC	OS	Quartile	II,III,IV	0.874	0.764	.032	4	view →
LSCC	OS	Median	All	0.729	0.866	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HEXB–COAD (DFS)

Open the COAD breakdown →