HEXB

Across TCGA patient cohorts, HEXB mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEXB-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and eIF4E. Each is linked with HEXB in more than 1 cancer types. Because this analysis shows association rather than direction, both HEXB-to-partner and partner-to-HEXB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by HEXB-low versus HEXB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEXB→partner) and Y-score (partner→HEXB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.137	+1.807	.020	.027	3	2
UCEC	EGFR_pY1068 →	-0.274	-4.087	.008	<.001	3	1
UCEC	eIF4E →	+0.183	+1.807	.035	.027	3	1
UCEC	ERK2 →	+0.204	+3.459	.010	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-2.584	.004	.010	3	1
UCEC	JNK2 →	+0.237	+2.348	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

C-Raf by HEXB expression — UCEC

Explore this box plot interactively →