HEXA-AS1

Across TCGA pan-cancer cohorts, HEXA-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HEXA-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher HEXA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HEXA-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and PRAD show a favorable association.

KICH, SKCM, and MESO are the cancer types where HEXA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	II,III,IV	0.684	1.000	.001	84	view →
SKCM	OS	Quartile	II,III,IV	0.673	0.838	.002	36	view →
MESO	DFS	Quartile	All	0.154	0.668	.006	24	view →
READ	OS	Median	II,III,IV	0.953	0.415	.001	17	view →
CESC	DFS	Median	II,III,IV	0.346	0.616	.028	14	view →
PRAD	DFS	Tertile	All	0.970	0.896	<.001	14	view →
KIRC	DFS	Median	IV	0.538	0.689	.033	12	view →
LAML	DFS	Tertile	All	0.481	0.683	.014	12	view →
UCS	DFS	Tertile	III,IV	0.513	0.140	.024	12	view →
KIRP	OS	Tertile	All	0.984	0.887	.001	11	view →
SARC	OS	Quartile	All	0.809	0.680	.021	10	view →
LGG	DFS	Median	All	0.776	0.869	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

HEXA-AS1–KICH (DFS)

Open the KICH breakdown →