HEXA-AS1

Across TCGA pan-cancer cohorts, HEXA-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HEXA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HEXA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HEXA-AS1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where HEXA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEXA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.503	<.001	11	view →
COAD	Female	II,III,IV	−0.425	<.001	10	view →
LIHC	Male	All	+0.341	<.001	8	view →
THCA	Male	All	−0.407	<.001	7	view →
BLCA	All	IV	+0.292	.008	7	view →
CHOL	Male	All	+0.351	.002	4	view →
HNSC	Male	II,III,IV	−0.175	.026	4	view →
STAD	All	All	+0.176	.011	3	view →
KICH	Male	All	−0.495	.039	1	view →
READ	All	All	−0.302	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HEXA-AS1–KIRC

Open the KIRC breakdown →