HESX1

Across TCGA patient cohorts, HESX1 mutation is significantly associated with the RNA expression of many other genes, with 726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HESX1-associated genes across cancer lineages are SRSF1P1, EZH2P1, and NFKBIB. Each is linked with HESX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HESX1-to-partner and partner-to-HESX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRSF1P1 grouped by HESX1-low versus HESX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HESX1→partner) and Y-score (partner→HESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SRSF1P1 →	+0.103	+3.357	<.001	.006	3	2
COAD	EZH2P1 →	+0.404	+3.337	.005	.001	3	2
UCEC	NFKBIB →	+0.486	+2.332	<.001	.003	3	2
UCEC	MEIG1 →	-0.571	-3.435	.006	.005	3	2
UCEC	TRBJ2-2P →	+1.371	+3.339	<.001	<.001	3	2
UCEC	TRDV1 →	+0.629	+2.454	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 726 associations by consensus.

SRSF1P1 by HESX1 expression — COAD

Explore this box plot interactively →