HESX1

Across TCGA pan-cancer cohorts, HESX1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HESX1 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HESX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HESX1 expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

KIRC, KICH, and LGG are the cancer types where HESX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.544	0.707	<.001	101	view →
KICH	DFS	Median	All	0.687	1.000	<.001	82	view →
LGG	DFS	Median	All	0.628	0.836	<.001	53	view →
CESC	DFS	Tertile	II,III,IV	0.804	0.536	.007	52	view →
SKCM	OS	Tertile	All	0.414	0.219	<.001	51	view →
ACC	DFS	Tertile	All	0.226	0.901	.001	42	view →
READ	OS	Median	III,IV	0.813	0.283	.001	26	view →
MESO	OS	Tertile	All	0.515	0.314	.007	21	view →
UCEC	DFS	Quartile	All	0.593	0.810	.003	18	view →
HNSC	DFS	Quartile	IV	0.451	0.292	.008	15	view →
THYM	OS	Median	II,III,IV	0.885	1.000	.009	14	view →
STAD	OS	Median	III,IV	0.480	0.288	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HESX1–KIRC (OS)

Open the KIRC breakdown →