HESX1

Across TCGA patient cohorts, HESX1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HESX1-associated genes across cancer lineages are Caspase-7-cleavedD198, Bid, and Notch1. Each is linked with HESX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HESX1-to-partner and partner-to-HESX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HESX1-low versus HESX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HESX1→partner) and Y-score (partner→HESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.733	+2.341	.003	.019	3	3
COAD	Bid →	+0.139	+2.832	.026	.035	3	2
UCEC	Notch1 →	+0.181	+2.472	.002	.010	3	2
UCEC	PDCD4 →	-0.507	-3.169	.011	.018	3	2
UCEC	Annexin-1 →	+0.602	+3.341	.007	.005	3	2
UCEC	TSC1 →	-0.174	-2.321	.017	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by HESX1 expression — UCEC

Explore this box plot interactively →