HESX1

Across TCGA cell cohorts, HESX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,023 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HESX1-associated GO terms across cancer lineages are Regulation of activin receptor signaling pathway, Intraciliary retrograde transport, and Adiponectin-activated signaling pathway. Each is linked with HESX1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HESX1-to-partner and partner-to-HESX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of activin receptor signaling pathway grouped by HESX1-low versus HESX1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HESX1→partner) and Y-score (partner→HESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of activin receptor signaling pathway →	-0.106	-0.487	.001	.009	3	9
LUNG_NSCLC_LUSC	Intraciliary retrograde transport →	+0.091	+0.562	.001	.002	3	8
LUNG_NSCLC_LUAD	Adiponectin-activated signaling pathway →	+0.095	+0.375	<.001	.007	3	8
LIVER	Cardiolipin metabolic process →	+0.082	+0.491	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Intraciliary anterograde transport →	+0.073	+0.425	.002	.007	3	8
KIDNEY	Protein localization to heterochromatin →	+0.164	+0.635	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,023 associations by consensus.

Regulation of activin receptor signaling pathway by HESX1 expression — URINARY_TRACT

Explore this box plot interactively →