HESX1

Across TCGA cell cohorts, HESX1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,988 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HESX1-associated genes across cancer lineages are CFAP36, NEIL2, and KRT8. Each is linked with HESX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HESX1-to-partner and partner-to-HESX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HESX1 versus CFAP36 in LUNG_NSCLC_LUSC, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HESX1→partner) and Y-score (partner→HESX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CFAP36 →	+1.022	+1.410	.003	.004	2	5
LUNG_SCLC	NEIL2 →	+1.260	+0.785	<.001	.002	3	4
SKIN	KRT8 →	-1.222	-1.156	.005	.007	3	4
LARGE_INTESTINE	PDCL3 →	+0.661	+1.099	.003	.005	2	5
LARGE_INTESTINE	TSPAN1 →	-2.812	-1.012	.001	<.001	3	4
BLOOD_Myeloma	GLIPR2 →	+2.448	+1.119	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,988 associations by consensus.

HESX1 vs CFAP36 — LUNG_NSCLC_LUSC

Explore this scatter interactively →