HES6

Across TCGA patient cohorts, HES6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HES6-associated genes across cancer lineages are ZYXP1, RNU6-778P, and RNU7-164P. Each is linked with HES6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES6-to-partner and partner-to-HES6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZYXP1 grouped by HES6-low versus HES6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES6→partner) and Y-score (partner→HES6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZYXP1 →	+0.911	+7.741	<.001	.009	3	1
HNSC	RNU6-778P →	+0.278	+7.954	<.001	.008	3	1
HNSC	RNU7-164P →	+0.416	+7.954	<.001	.008	3	1
HNSC	RNU7-2P →	+0.417	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ZYXP1 by HES6 expression — COAD

Explore this box plot interactively →