HES6

Across TCGA pan-cancer cohorts, HES6 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HES6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HES6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HES6 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRP, and HNSC are the cancer types where HES6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HES6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+2.200	<.001	11	view →
KIRP	All	II,III,IV	+1.477	<.001	11	view →
HNSC	All	All	+1.167	<.001	10	view →
THCA	Male	All	+1.841	<.001	9	view →
LIHC	Male	All	+1.498	<.001	9	view →
STAD	Male	II,III,IV	+1.926	<.001	8	view →
LUAD	Male	All	+1.701	<.001	8	view →
UCEC	All	II,III,IV	+3.132	<.001	6	view →
BRCA	All	II,III,IV	+1.652	<.001	6	view →
LUSC	All	All	+1.062	<.001	4	view →
CHOL	All	All	+1.822	.005	3	view →
READ	Female	All	+1.809	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HES6–COAD

Open the COAD breakdown →