HES6

Across TCGA cell cohorts, HES6 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HES6-associated genes across cancer lineages are SPATA31E1, STH, and LILRA1. Each is linked with HES6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES6-to-partner and partner-to-HES6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31E1 grouped by HES6-low versus HES6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES6→partner) and Y-score (partner→HES6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPATA31E1 →	+0.166	+4.906	<.001	.006	3	1
OESOPHAGUS	STH →	+0.076	+4.906	<.001	.006	3	1
LARGE_INTESTINE	LILRA1 →	+0.013	+4.095	.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.178	+4.273	<.001	.006	3	1
LUNG_SCLC	OR13F1 →	+0.032	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.031	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SPATA31E1 by HES6 expression — OESOPHAGUS

Explore this box plot interactively →