HES6

Across TCGA cell cohorts, HES6 mutation is significantly associated with the mutation status of many other genes, with 1,238 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HES6-associated genes across cancer lineages are WDR37, TGM3, and MAOB. Each is linked with HES6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HES6-to-partner and partner-to-HES6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR37 grouped by HES6-low versus HES6-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES6→partner) and Y-score (partner→HES6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	WDR37 →	+5.502	+5.502	.003	.003	1	3
LARGE_INTESTINE	TGM3 →	+2.865	+4.217	.007	.007	1	3
LUNG_SCLC	MAOB →	+4.502	+5.066	.007	.007	1	2
LUNG_NSCLC_LUAD	VIPAS39 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	DCLRE1C →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	DDX4 →	+5.772	+5.772	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,238 associations by consensus.

WDR37 by HES6 expression — LUNG_SCLC

Explore this box plot interactively →