Across TCGA patient cohorts, HES5 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HES5-associated genes across cancer lineages are RNU6-591P, MIR1185-1, and FAM197Y1. Each is linked with HES5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HES5-to-partner and partner-to-HES5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES5→partner) and Y-score (partner→HES5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-591P →	+0.373	+7.741	<.001	.009	3	1
COAD	MIR1185-1 →	+0.465	+7.741	<.001	.009	3	1
COAD	FAM197Y1 →	+0.064	+7.741	<.001	.009	3	1
COAD	FAM41AY1 →	+0.054	+7.741	<.001	.009	3	1
COAD	MIR5689 →	+0.468	+7.741	<.001	.009	3	1
UCEC	MIR4476 →	+0.736	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

HES5 survival (RNA) · tumor vs normal (RNA) · all HES5 data types