HES3

Across TCGA patient cohorts, HES3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,409 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HES3-associated GO terms across cancer lineages are Exit from mitosis, tRNA transcription, and Establishment of tissue polarity. Each is linked with HES3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HES3-to-partner and partner-to-HES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Exit from mitosis grouped by HES3-low versus HES3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HES3→partner) and Y-score (partner→HES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Exit from mitosis →	+0.065	+0.091	<.001	<.001	3	9
STAD	tRNA transcription →	+0.050	+0.119	<.001	<.001	3	9
STAD	Establishment of tissue polarity →	+0.040	+0.103	<.001	<.001	3	9
STAD	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.059	+0.082	<.001	<.001	3	9
STAD	Transport along microtubule →	+0.056	+0.092	<.001	<.001	3	8
KIRC	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.031	+0.010	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,409 associations by consensus.

Exit from mitosis by HES3 expression — STAD

Explore this box plot interactively →