HES2

Across TCGA patient cohorts, HES2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,575 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HES2-associated proteins across cancer lineages are PDLIM1, PPP1R13L, and PPP1R9A_S840. Each is linked with HES2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HES2-to-partner and partner-to-HES2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HES2 versus PDLIM1 in UCEC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HES2→partner) and Y-score (partner→HES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDLIM1 →	+0.523	+1.315	<.001	<.001	3	5
HNSC	PPP1R13L →	+0.477	+0.950	<.001	<.001	3	5
HNSC	PPP1R9A_S840 →	-1.347	-1.279	.001	.001	3	5
BRCA	KRT6A →	+1.413	+0.974	.002	.001	3	5
LSCC	LAMB3 →	+0.756	+0.831	<.001	.001	3	5
BRCA	LAMC2 →	+0.872	+0.805	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,575 associations by consensus.

HES2 vs PDLIM1 — UCEC

Explore this scatter interactively →