HES2

Across TCGA pan-cancer cohorts, HES2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HES2 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher HES2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HES2 expression acts as an unfavorable survival marker, although some lineages such as KIRP and DLBC show a favorable association.

MESO, ACC, and KIRP are the cancer types where HES2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.423	0.665	<.001	93	view →
ACC	DFS	Median	All	0.255	0.614	<.001	89	view →
KIRP	OS	Tertile	All	0.962	0.802	<.001	79	view →
UVM	DFS	Tertile	II,III,IV	0.322	0.762	.001	56	view →
BLCA	OS	Tertile	IV	0.196	0.750	.001	55	view →
SKCM	OS	Tertile	All	0.701	0.820	<.001	39	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	22	view →
LUSC	DFS	Quartile	II,III,IV	0.739	0.499	.003	17	view →
LIHC	OS	Quartile	All	0.439	0.708	<.001	16	view →
SCLC	DFS	Quartile	III,IV	0.662	0.242	.009	14	view →
LGG	DFS	Quartile	All	0.752	0.866	.005	14	view →
KIRC	DFS	Quartile	II,III,IV	0.601	0.767	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HES2–MESO (OS)

Open the MESO breakdown →