HES2

Across TCGA patient cohorts, HES2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,943 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HES2-associated genes across cancer lineages are MGAT3, MGAT3-AS1, and DNAH6. Each is linked with HES2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HES2-to-partner and partner-to-HES2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HES2 versus MGAT3 in LUAD, with a Pearson correlation of 0.89.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HES2→partner) and Y-score (partner→HES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MGAT3 →	+1.500	+0.983	.001	.002	3	4
LUAD	MGAT3-AS1 →	+1.326	+0.979	.001	.002	3	4
UCEC	DNAH6 →	+0.729	+0.507	.008	.001	3	2
UCEC	ROPN1L →	+1.614	+0.541	<.001	<.001	3	2
UCEC	LRRC43 →	+1.022	+0.981	.002	<.001	3	2
UCEC	C5orf49 →	+1.130	+0.480	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,943 associations by consensus.

HES2 vs MGAT3 — LUAD

Explore this scatter interactively →