HERC4

Across TCGA cell cohorts, HERC4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HERC4-associated genes across cancer lineages are LCE2A, CCDC140, and IL9. Each is linked with HERC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC4-to-partner and partner-to-HERC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE2A grouped by HERC4-low versus HERC4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC4→partner) and Y-score (partner→HERC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	LCE2A →	+0.060	+4.954	<.001	<.001	3	2
KIDNEY	CCDC140 →	+0.176	+4.121	<.001	.006	3	1
BREAST	IL9 →	+0.026	+3.781	<.001	.009	3	1
BREAST	KLK12 →	+0.642	+4.058	<.001	.001	3	1
BREAST	OR13C2 →	+0.015	+3.727	<.001	.002	3	1
BREAST	CBLN4 →	+0.004	+3.727	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

LCE2A by HERC4 expression — KIDNEY

Explore this box plot interactively →