Across TCGA patient cohorts, HERC2P9 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC2P9-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with HERC2P9 in more than 1 cancer types. Because this analysis shows association rather than direction, both HERC2P9-to-partner and partner-to-HERC2P9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2P9→partner) and Y-score (partner→HERC2P9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.206	-1.678	.027	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.927	+3.807	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.241	+2.199	.020	.033	3	2
UCEC	EGFR_pY1068 →	-0.303	-2.087	.001	.005	3	1
UCEC	ERK2 →	+0.178	+2.087	.015	.005	3	1
UCEC	FoxM1 →	+0.244	+2.087	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

HERC2P9 survival (RNA) · tumor vs normal (RNA) · all HERC2P9 data types