HERC2P5

Across TCGA patient cohorts, HERC2P5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,258 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HERC2P5-associated GO terms across cancer lineages are Regulation of DNA-templated transcription elongation, Obsolete histone modification, and Regulation of transcription elongation by RNA polymerase II. Each is linked with HERC2P5 in more than 25 cancer types. Because this analysis shows association rather than direction, both HERC2P5-to-partner and partner-to-HERC2P5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription elongation grouped by HERC2P5-low versus HERC2P5-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2P5→partner) and Y-score (partner→HERC2P5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of DNA-templated transcription elongation →	+0.050	+0.115	.004	<.001	2	26
STAD	Obsolete histone modification →	+0.045	+0.044	<.001	<.001	3	24
STAD	Regulation of transcription elongation by RNA polymerase II →	+0.046	+0.042	<.001	<.001	3	24
THYM	Obsolete histone H3-K4 methylation →	+0.075	+0.169	<.001	<.001	3	24
THYM	Transcription elongation-coupled chromatin remodeling →	+0.063	+0.172	<.001	<.001	3	24
STAD	DNA biosynthetic process →	+0.047	+0.050	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,258 associations by consensus.

Regulation of DNA-templated transcription elongation by HERC2P5 expression — ESCA

Explore this box plot interactively →