HERC2P5

Across TCGA pan-cancer cohorts, HERC2P5 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HERC2P5 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HERC2P5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HERC2P5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LUSC, KIRC, and LUAD are the cancer types where HERC2P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	II,III,IV	0.207	0.600	.004	39	view →
KIRC	OS	Tertile	All	0.871	0.773	.005	34	view →
LUAD	DFS	Quartile	IV	0.395	0.906	.008	20	view →
LIHC	OS	Quartile	All	0.666	0.804	.004	19	view →
READ	OS	Quartile	All	0.955	0.520	.007	16	view →
PRAD	DFS	Tertile	All	0.881	0.941	.011	12	view →
THYM	DFS	Median	III,IV	1.000	0.463	.009	11	view →
ACC	OS	Tertile	IV	0.251	0.776	.009	11	view →
UVM	OS	Tertile	All	0.720	0.358	.037	10	view →
PAAD	OS	Tertile	All	0.636	0.420	.013	10	view →
CHOL	OS	Tertile	II,III,IV	0.391	0.825	.036	9	view →
BRCA	DFS	Tertile	III,IV	0.938	0.837	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HERC2P5–LUSC (OS)

Open the LUSC breakdown →