HERC2

Across TCGA cell cohorts, HERC2 mutation is significantly associated with the RNA expression of many other genes, with 1,628 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HERC2-associated genes across cancer lineages are RAB29, TBL1X, and BBS4. Each is linked with HERC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HERC2-to-partner and partner-to-HERC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB29 grouped by HERC2-low versus HERC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC2→partner) and Y-score (partner→HERC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAB29 →	+0.768	+1.254	<.001	<.001	3	5
LUNG_NSCLC_LUAD	TBL1X →	+0.777	+3.321	.003	.004	3	4
LARGE_INTESTINE	BBS4 →	+0.492	+0.981	.002	.007	3	4
CNS	ZNF624 →	+0.419	+3.807	<.001	<.001	3	4
CNS	FAM171A2 →	+0.980	+3.392	<.001	.001	3	4
SOFT_TISSUE	OR9A4 →	+0.029	+5.369	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,628 associations by consensus.

RAB29 by HERC2 expression — LARGE_INTESTINE

Explore this box plot interactively →