HERC1

Across TCGA pan-cancer cohorts, HERC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HERC1 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher HERC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HERC1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM, LUAD, and LSCC are the cancer types where HERC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.840	0.644	.001	23	view →
LUAD	DFS	Median	All	0.619	0.850	.001	20	view →
LSCC	DFS	Tertile	All	0.268	0.859	.010	8	view →
PDAC	DFS	Median	II,III,IV	0.319	0.454	.019	8	view →
CCRCC	DFS	Tertile	III,IV	0.080	0.981	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HERC1–GBM (DFS)

Open the GBM breakdown →