HERC1

Across TCGA pan-cancer cohorts, HERC1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HERC1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HERC1 RNA is repressed in tumor relative to normal tissue. In most cancer types HERC1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where HERC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HERC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−1.072	<.001	10	view →
LIHC	Female	II,III,IV	+1.010	<.001	7	view →
UCEC	All	All	−1.190	<.001	6	view →
BRCA	All	III,IV	−0.680	<.001	6	view →
LUAD	Female	All	−0.627	<.001	6	view →
CHOL	All	All	+1.026	<.001	5	view →
BLCA	All	All	−0.523	.014	5	view →
LUSC	Male	All	−0.521	<.001	4	view →
COAD	All	II,III,IV	−0.369	.003	4	view →
READ	All	All	−0.592	.020	2	view →
KIRP	Male	All	−0.581	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HERC1–THCA

Open the THCA breakdown →