HERC1

Across TCGA patient cohorts, HERC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,794 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HERC1-associated proteins across cancer lineages are GRPEL1, RPL5, and CNRIP1. Each is linked with HERC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HERC1-to-partner and partner-to-HERC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC1 versus GRPEL1 in PDAC, with a Pearson correlation of -0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC1→partner) and Y-score (partner→HERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GRPEL1 →	-0.502	-0.338	<.001	<.001	3	7
GBM	RPL5 →	-0.214	-0.240	<.001	.004	3	7
BRCA	CNRIP1 →	+0.543	+0.580	<.001	<.001	3	6
BRCA	HDGFL3 →	+0.708	+0.464	<.001	<.001	3	6
GBM	RPS3A →	-0.164	-0.221	<.001	<.001	3	6
LSCC	FAM98B →	+0.346	+0.353	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,794 associations by consensus.

HERC1 vs GRPEL1 — PDAC

Explore this scatter interactively →