HERC1

Across TCGA patient cohorts, HERC1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,080 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HERC1-associated genes across cancer lineages are TGFBR2, STAMBPL1, and ANTXR2. Each is linked with HERC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HERC1-to-partner and partner-to-HERC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HERC1 versus TGFBR2 in GBM, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC1→partner) and Y-score (partner→HERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TGFBR2 →	-0.580	-0.153	<.001	<.001	3	5
LSCC	STAMBPL1 →	-0.597	-0.171	<.001	<.001	3	4
LSCC	ANTXR2 →	-0.629	-0.119	.001	.007	3	4
LUAD	TRANK1 →	-0.744	-0.227	<.001	<.001	3	4
LSCC	TICRR →	+1.062	+0.179	<.001	<.001	3	4
GBM	PBK →	+0.988	+0.126	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,080 associations by consensus.

HERC1 vs TGFBR2 — GBM

Explore this scatter interactively →