HERC1

Across TCGA patient cohorts, HERC1 mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HERC1-associated genes across cancer lineages are Caspase-7-cleavedD198, Rab25, and PCNA. Each is linked with HERC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HERC1-to-partner and partner-to-HERC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HERC1-low versus HERC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC1→partner) and Y-score (partner→HERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.857	+3.459	.004	.004	2	6
BLCA	Rab25 →	+0.376	+2.321	.015	.033	3	4
STAD	PCNA →	+0.332	+3.584	.004	.002	2	5
BRCA	p38-MAPK_pT180_Y182 →	-0.600	-3.315	<.001	.011	3	3
LUSC	ACC_pS79 →	+0.356	+2.424	.004	.001	3	3
LUSC	CD31 →	-0.184	-1.897	.002	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

Caspase-7-cleavedD198 by HERC1 expression — STAD

Explore this box plot interactively →