HERC1

Across TCGA cell cohorts, HERC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,501 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HERC1-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Heterochromatin organization, and Cytosolic transport. Each is linked with HERC1 in more than 16 cancer types. Because this analysis shows association rather than direction, both HERC1-to-partner and partner-to-HERC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by HERC1-low versus HERC1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC1→partner) and Y-score (partner→HERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.073	+0.643	<.001	<.001	3	17
BONE	Heterochromatin organization →	+0.084	+0.747	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.078	+0.976	<.001	.001	3	17
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.128	+0.747	.001	.009	3	16
KIDNEY	RNA polymerase II promoter clearance →	+0.128	+0.747	.001	.009	3	16
BONE	Microtubule polymerization →	+0.102	+0.735	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,501 associations by consensus.

Epigenetic regulation of gene expression by HERC1 expression — LUNG_SCLC

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