HERC1

Across TCGA cell cohorts, HERC1 mutation is significantly associated with the RNA expression of many other genes, with 1,722 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HERC1-associated genes across cancer lineages are MAD2L2, CSH1, and SCLY. Each is linked with HERC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HERC1-to-partner and partner-to-HERC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAD2L2 grouped by HERC1-low versus HERC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HERC1→partner) and Y-score (partner→HERC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAD2L2 →	+0.714	+2.380	.003	.008	3	4
LUNG_NSCLC_LUAD	CSH1 →	+0.033	+1.928	<.001	.009	3	3
LARGE_INTESTINE	SCLY →	+0.530	+1.808	.001	.001	3	3
LARGE_INTESTINE	TGS1 →	+0.457	+3.257	.002	.002	3	3
LARGE_INTESTINE	OXA1L →	+0.350	+2.526	.003	.002	3	3
BLOOD_Leukemia	HASPIN →	+0.615	+2.630	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,722 associations by consensus.

MAD2L2 by HERC1 expression — BLOOD_Leukemia

Explore this box plot interactively →