Across TCGA pan-cancer cohorts, HEPN1 Mutation is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated HEPN1 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HEPN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HEPN1 expression acts as an unfavorable survival marker.

LUAD, SKCM, and PRAD are the cancer types where HEPN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.323	0.834	.003	12	view →
SKCM	DFS	Median	All	0.146	0.740	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HEPN1 tumor-vs-normal RNA expression · all HEPN1 data types