Across TCGA cell cohorts, HEPN1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEPN1-associated genes across cancer lineages are FTMT, DEFA4, and CLPSL1. Each is linked with HEPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPN1-to-partner and partner-to-HEPN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPN1→partner) and Y-score (partner→HEPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CLPSL1 →	+0.158	+4.054	<.001	.004	3	1
LARGE_INTESTINE	PPEF2 →	+0.050	+3.736	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

HEPN1 survival (RNA) · tumor vs normal (RNA) · all HEPN1 data types